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Genetic Susceptibility to Noise-Induced Hearing Loss
An international team of neuroscientists from the University of Southern California have authored a new genome-wide association study that suggests some people may be more genetically predisposed to noise-induced hearing loss than others. The study examined the biological processes that can affect a vulnerability towards hearing loss caused by noise exposure, and identified a gene that could be the key. This is not the first study on the link between noise-related hearing loss and genetics, but this is the first large study that successfully replicated their results and published their findings. Researchers used mice as test subjects and identified the Nox3 gene, which is expressed almost entirely in the inner ear, as the link to hearing loss vulnerability. While more research is necessary before any there are any clinical implications, this gene could be very important in the future. People could be tested for genetic susceptibilities, and take more precautions against excessive noise in order to protect their hearing.Cognitive Shifts Due to Hearing Loss
A group of researchers at the University of Colorado have found that hearing loss may cause dramatic brain shifts in both children and adults. Using electroencephalographic (EEG) recordings of subjects with deafness and hearing loss, the group at the Department of Speech Language and Hearing Science was able to measure brain activity in response to auditory stimulation.
Researchers discovered that the areas of the brain that process vision or touch can take over the areas that would normally process hearing, but receive very little stimulation when a person is deaf or hard of hearing. This change is termed cross- modal cortical reorganization and reveals how adaptable the brain is, in response to its environmental changes. The study showed that this cortical reorganization was apparent in even patients with only mild hearing loss. Researchers concluded that this adaptation can decrease the brain’s propensity for processing sound, which can in turn affect a deaf patient’s ability to understand speech with cochlear implants. The group also suggested that the brain’s compensations for hearing loss can increase the overall workload on the brains of aging people, which could significantly correlate with dementia. Researchers demonstrated that examining cortical reorganization can be a valuable tool to create therapies and rehabilitation strategies for those with cochlear implants.



